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The renin-aldosterone link is mediated by angiotensin II, so coadministration of an angiotensin II receptor antagonist tends to reverse the potassium decline related to these diuretics.

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Blockade from the AT1 receptor removes the destructive feed-back of angiotensin II on renin secretion, nevertheless the resulting increased plasma renin exercise and circulating angiotensin II do not get over the results of irbesartan on blood pressure.

The selection of Irbesartan & Hydrochlorothiazide tablets as Preliminary therapy for hypertension ought to be according to an assessment of prospective Rewards and dangers.

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